Nutribén® Innova® 1

1. Estudio del efecto de diferentes alimentos infantiles suplementados con la cepa bacteriana BPL1 inactiva sobre la acumulación de lípidos en el modelo in vivo de Caenorhabditis elegans. Estudio interno. No publicado, dic. 2015.

2. Probiotic StrainBifidobacterium animalissubsp. lactis CECT 8145 Reduces Fat Content and Modulates Lipid Metabolism and Antioxidant Response in Caenorhabditis elegans Patricia Martorell, Silvia Llopis, Nuria González, Empar Chenoll, Noemi López-Carreras, Amaya Aleixandre, Yang Chen, Edwuard D. Karoly, Daniel Ramón and Salvador Genovés J. Agric. Food Chem., 2016, 64 (17), pp 3462–3472.

3. Nueva cepa deBifidobacterium animalissubsp. lactis CECT 8145 y su uso para el tratamiento y/o prevención de sobrepeso y obesidad y enfermedades asociadas. Oficina española de patentes y marcas. Número de publicación: 2 526 986.

4. Evaluación del efecto sobre la modulación del microbioma de la cepa BPL1 inactivada en “faecal slurries” Estudio interno, no publicado. Diciembre 2016.

5. Heat-killedBifidobacterium animalisCECT 8145 increases lean mass, attenuates adiposity and dyslipidaemia and improves insulin sensitivity in cafeteria-fed rats. Nutrition and Health Research Group (GRNS), Technological Centre for Nutrition and Health (CTNS), Tecnio, Campus de Excelencia Internacional Cataluña Sur (CEICS), Reus, Spain. Cell Biology Laboratory, Food Biotechnology Department, Biópolis SL, Paterna, 46980 Valencia, Spain. Nutrigenomics Research Group, Department of Biochemistry and Biotechology, Universitat Rovira i Virgili, Tarragona, Spain. 2016 Pendiente de publicación.

6. Effect of the strainBifidobacterium animalissubsp. lactis CECT 8145 in Zücker fatty rats. Noemi López Carreras, Patricia Martorell, Empar Chenoll, Salvador Genovés, Daniel Ramón and Amaya Aleixandre. Departamento de Farmacología, Facultad de Medicina, Universidad Complutense de Madrid, Avenida Complutense s/n, 28040 Madrid, Spain. Department of Food Biotechnology; Biópolis S.L. Parc Científic Universitat De València, Edif. 2, C/ Catedrático Agustín Escardino Benlloch, 9, 46980 Paterna (Valencia), Spain. 2016 Pendiente de publicación.

7. Recomendaciones sobre lactancia materna del Comité de Lactancia Materna de la Asociación Española de Pediatría.

8. Infant formulas with increased concentrations of alfa-lactalbumin. Eric L. Lien. Am. J. Clin Nutr 2003:77 (suppl): 1555s-8s v.

9.Alpha-lactalbumin enriched low-protein infant formulas: a comparison to breast-milk feeding. Heine WE, Radke M, Wutzke KD, Peters E, Kundt G. Acta Paeditr 1996; 85:1024-8.

10. OMS (Organización Mundial de la Salud)

11. Estrategia NAOS (Ministerio de Sanidad y Consumo)

Nutribén® Innova® 2

1. Weber M y cols. Lower protein content in infant formula reduces BMI and obesity risk at school age: follow-up of a randomized trial. Am J Clin Nutr 2014;99:1041-51.

2. Koletzko B y cols: Can infant feeding choices modulate later obesity risk? Am J Clin Nutr 2009;89 (5):1502S – 8S.

3. OMS (Organización Mundial de la Salud).

4. Estrategia NAOS (Ministerio de Sanidad y Consumo).

Nutribén® Innova® 3

1. Weber M y cols. Lower protein content in infant formula reduces BMI and obesity risk at school age: follow-up of a randomized trial. Am J Clin Nutr 2014;99:1041-51.

2. Koletzko B y cols: Can infant feeding choices modulate later obesity risk? Am J Clin Nutr 2009;89 (5):1502S – 8S.

3. OMS (Organización Mundial de la Salud).

4. Estrategia NAOS (Ministerio de Sanidad y Consumo).

Nutribén® Natal 1

1. Infant formulas with increased concentrations of alfa-lactalbumin. Eric L. Lien. Am. J. Clin Nutr 2003:77 (suppl): 1555s-8s

2. Indices of protein metabolism in term infants fed Esther human milk of formulas with reduced protein concentrations and various whey/casein ratio. Janas LM, Picciano MF, Räihä NCR; Heinonen K. J. Paediatr, 1987.110: 838-848

3. Alpha-lactalbumin- enriched low-protein infant formulas: a comparison to breast-milk feeding. Heine WE, Radke M, Wutzke KD, Peters E, Kundt G. Acta Paeditr 1996; 85: 1024-8

4. In Vitro digestion of cows milk protein by duodenal juice from infants with various intestinal disorders. Jakobson I, Lindberg T, Benediktson B. J. Paediatr. Gastroenterol. Nutri, 1982: 1:183-191

5.Advances in nutritional modifications of infant formulas. Carver DJ. Am. J. Clin. Nutr. 2003; 77 (suppl): 1550s-4s

6. Dietary sources of nucleotides- from breast milk to weaning. Barness LA. J. Nutr. 1994: 128s-130s

7. Dietary nucleotides: cellular immune, intestinal and hepatic system effects. J. Nutr 1994: 124: 144-8s

8. Modulation of the immune system by human milk and infant formula containing nucleotides. Pikering LK, Granoff DM, Erickson JR, Masor ML and cols. American Academy of Pediatrics. 1998; 101: 242-249

9. Alimentos funcionales. La importancia de los alimentos funcionales en las leches y papillas infantiles. Rivero Urgell M, Santamaría Orleáns A, Rodríguez Palmero, Seuma Mª. Nutrición Hospitalaria 2005; XX (2): 135-146

10. Nucleotide supplementation and the growth of term small for gestational age infants. Cosgrove M. (1996) Arch Dis Child 74 (f122-f125)

11. Visual acuity, erythrocyte fatty acid composition and growth in term infants fed formulas with long chain polyunsaturated fatty acid for one year. Auestad N.; Montalvo MB.; Hall RT y Cols: Pediatr Res 1997; 41: 1 – 10

12.The roles of long chain polyunsaturated fatty acids in pregnancy, lactation and infancy: review of the current knowledge and consensus recommendations. B. Koleztko, E. Lien, C. Agostini et al. J. Perinat Med 2008; 36 (1): 5-14

13.Neurodevelopmental quotient of healthy term infants at 4 months and feeding practice: the role of long chain polyunsaturated fatty acids. C. Agostini, S. Trijan, R. Bellu, E. Riva, M. Giovanni. Pediatr Res 1995; 38: 262-26

14 Low level of galacto-oligosaccharide in infant formula stimulates growth of intestinal Bifidobacteria and Lactobacilli. Ben XM, Li J Fen_ ZT, et al World J Gastroenterol 2008 November 14; 14(42) 6564-6568

15 The role of prebiotics and probiotics in pediatric practice. M. Batista de Moaris, C. Miuki Abe Jacob. Jornal de Pediatrica (Rio Janeiro) 200

16 Probiotics, prebiotics and symbiotics: approaches for modulating the microbial ecology of the gut. Collins MD, Gibson GR, Am J Clin Nutr 1999; 69(supl):1052s-1057

17. Report of the Scientific Committee on food on the revision of essential requirements of infant formulae and follow-on formulae (adopted on 4 April 2003) SCF/CS/NUT/IF/65 Final, 18 may 2003

Nutribén® AC Digest

1. Infantile colic: crying time reduction with a whey hydrolysate: A double-blind, randomized, placebo-controlled trial. Pediatrics. 2000; 106: 1349-54 Lucassen PL, Assendelft WJ, Gubbels JW, van Eijk JT, Douwes AC.

2. Effectiveness of treatments for infantile colic: systematic review. BMJ 1998; 23; 316: 1563-9. (Erratum in: BMJ 1998 Jul 18;317(7152):171 Lucassen PL, Assendelft WJ, Gubbels JW, van Eijk JT, van Geldrop WJ, Neven AK.

3. Dietary nucleotides: cellular immune, intestinal and hepatic system effects. J. Nutr 1994: 124: 144-8s

4. Modulation of the immune system by human milk and infant formula containing nucleotides. Pikering LK, Granoff DM, Erickson JR, Masor ML and cols. American Academy of Pediatrics. 1998; 101: 242-249

5. A trial of lactase in the management of infant colic. Kearney PJ, Malone AJ, Hayes T, Cole M, Hyland M. J Hum Nutr and Dietet 1998; 11: 281-5

6. Improvement of symptoms in infant colic following reduction of lactose load with lactase Kanabar D, Randhawa M, Clayton P. J Hum Nutr Diet. 2001; 14: 359-63

7. Breath hydrogen response to milk containing lactose in colicky and no colicky infants Moore DJ, Robb TA, Davidson GP.. The Journal of Pediatrics, December 1988. Vol 113; number 6.

8. Visual acuity, erythrocyte fatty acid composition and growth in term infants fed formulas with long chain polyunsaturated fatty acid for one year. Auestad N.; Montalvo MB.; Hall RT y Cols: Pediatr Res 1997; 41: 1 – 10

9. The roles of long chain polyunsaturated fatty acids in pregnancy, lactation and infancy: review of the current knowledge and consensus recommendations. B. Koleztko, E. Lien, C. Agostini et al. J. Perinat Med 2008; 36 (1): 5-14.

10. Neurodevelopmental quotient of healthy term infants at 4 months and feeding practice: the role of long chain polyunsaturated fatty acids. C. Agostini, S. Trijan, R. Bellu, E. Riva, M. Giovanni. Pediatr Res 1995; 38: 262-26.

11. Report of the Scientific Committee on food on the revision of essential requirements of infant formulae and follow- on formulae (adopted on 4 April 2003) SCF/CS/NUT/IF/65 Final, 18 May 2003

Nutribén® A.E. 1 y Nutribén® A.E. 2

1. Double-blind, randomized trial of a synthetic triacylglycerol in formula fed-term infants: effects on stool biochemistry, stool characteristics, and bone mineralization Kennedy K, Fewtrell MS, Morley R, Abbott R, Quilan PT, Wells JCK, et al.. Am J Clin Nutr 1999; 70: 920-7

2. Structural position and amount of palmitic acid in infant formulas: effects on fat, fatty acid, and mineral balance. Carnielli VP, Luijendijk IHT, Van Goudoever JB, Sulkers EJ, Boerlage AA, Degenhart HJ, et al. J Pediatr Gastroenterol Nutr 1996; 23: 553-60

3. The roles of long chain polyunsaturated fatty acids in pregnancy, lactation and infancy: review of the current knowledge and consensus recommendations. B. Koleztko, E. Lien, C. Agostini et al. J. Perinat Med 2008; 36 (1): 5-14.

4. Low level of galacto-oligosaccharide in infant formula stimulates growth of intestinal Bifidobacteria and Lactobacilli. Ben XM, Li J Fen_ ZT, et al World J Gastroenterol 2008 November 14; 14(42) 6564-6568.

5. Dietary nucleotides: cellular immune, intestinal and hepatic system effects. J. Nutr 1994: 124: 144-8s

6. Modulation of the immune system by human milk and infant formula containing nucleotides. Pikering LK, Granoff DM, Erickson JR, Masor ML and cols. American Academy of Pediatrics. 1998; 101: 242-249

Nutribén® RN Bajo Peso

1. Feeding Preterm Infants After Hospital Discharge A Commentary by the ESPGHAN Committee on Nutrition ESPGHAN Committee on Nutrition: Peter J. Aggett2, Carlo Agostoni, Irene Axelsson, Mario De Curtis, Olivier Goulet, Olle Hernell, LBerthold Koletzko1, Harry N. Lafeber, Kim F. Michaelsen, John W.L. Puntis, Jacques Rigo, Raanan Shamir, Hania Szajewska, Dominique Turck, and Lawrence T. Weaver

2. Effects of a low birthweight infant formula containing human milk levels of docosahexaenoic and arachidonic acids. Koletzko, Edenhofer, Lipowsky, Reinhardt

3. Dietary nucleotides: cellular immune, intestinal and hepatic system effects. J. Nutr 1994: 124: 144-8s

4. Modulation of the immune system by human milk and infant formula containing nucleotides. Pikering LK, Granoff DM, Erickson JR, Masor ML and cols. American Academy of Pediatrics. 1998; 101: 242-249

Nutribén® Soja

1. Advances in nutritional modifications of infant formulas. Carver DJ. Am. J. Clin. Nutr. 2003; 77 (suppl): 1550s-4s

2. Dietary sources of nucleotides- from breast milk to weaning. Barness LA. J. Nutr. 1994: 128s-130s

3. Dietary nucleotides: cellular immune, intestinal and hepatic system effects. J. Nutr 1994: 124: 144-8s

4. Modulation of the immune system by human milk and infant formula containing nucleotides. Pikering LK, Granoff DM, Erickson JR, Masor ML and cols. American Academy of Pediatrics. 1998; 101: 242-249

5. Alimentos funcionales. La importancia de los alimentos funcionales en las leches y papillas infantiles. Rivero Urgell M, Santamaría Orleáns A, Rodríguez Palmero, Seuma Mª. Nutrición Hospitalaria 2005; XX (2): 135-146

6. Nucleotide supplementation and the growth of term small for gestational age infants. Cosgrove M. (1996) Arch Dis Child 74 (f122-f125)

7. Report of the Scientific Committee on food on the revision of essential requirements of infant formulae and follow-on formulae (adopted on 4 April 2003) SCF/CS/NUT/IF/65 Final, 18 may 2003

8. Comentario sobre la composición de las fórmulas infantiles de inicio y continuación a base de proteína de soja. Comité de Nutrición de la ESPGHAN. Acta Paediatrica Scandinavica. Volumen 79: 1001-1005, 1990

Nutribén® AR 1

1. Antireflux or Antiregurgitation milk products for infants and young children: A commentary by the ESPGHAN Committee on Nutrition. Journal of pediatric gastroenterology and nutrition 2002; 34: 496-49

2. Trainer tools: Carbohydrates. FN. Version 2.0 – Part I. Chapter 6

3. Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. Gibson GR, Roberfroid MB. J Nutr 1995; 125: 1401-1412

4. Dietary supplement of neosugar alters the faecal flora and decreases activities of some reductive enzymes in human subjects. Buddington RK et al. Am J Clin Nutr (1996); 63: 709-16

5. Dietary modulation of the human gut microflora using prebiotics. Gibson GR Br J Nutri 1998; 80:209-212

6. Prolifetation of bifidobacteria by oligosaccharides and their useful effect on human health. Hidaka H, Tashiro Y, Eida T. Bifidobacteria Microflora 1991; 10: 65-79.

7. Dietary nucleotides: cellular immune, intestinal and hepatic system effects. J. Nutr 1994: 124: 144-8s

8. Modulation of the immune system by human milk and infant formula containing nucleotides. Pikering LK, Granoff DM, Erickson JR, Masor ML and cols. American Academy of Pediatrics. 1998; 101: 242-24

9. Nucleotide supplementation and the growth of term small for gestational age infants. Cosgrove M. (1996) Arch Dis Child 74 (f122-f125)

10. Tratado de Nutrición Pediátrica. Capítulo 11: Lípidos y ácidos grasos. Tojo R. Pág. 147-162. Ed. Doyma S. L. 2001

11. Visual acuity, erythrocyte fatty acid composition and qrowth in term infants fed formulas with long chain polyunsaturated fatty acid for one year Auestad N.; Montalvo MB.; Hall RT y Cols:. Pediatr Res 1997; 41: 1 – 10

12. The roles of long chain polyunsaturated fatty acids in pregnancy, lactation and infancy: review of the current knowledge and consensus recommendations. B. Koleztko, E. Lien, C. Agostini et al. J. Perinat Med 2008; 36 (1): 5-14.

Nutribén® AR 2

1. Antireflux or Antiregurgitation milk products for infants and young children: A commentary by the ESPGHAN Committee on Nutrition. Journal of pediatric gastroenterology and nutrition 2002; 34: 496-49

2. Trainer tools: Carbohydrates. FN. Version 2.0 – Part I. Chapter 6

3. Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. Gibson GR, Roberfroid MB. J Nutr 1995; 125: 1401-1412

4. Dietary supplement of neosugar alters the faecal flora and decreases activities of some reductive enzymes in human subjects. Buddington RK et al. Am J Clin Nutr (1996); 63: 709-16

5. Dietary modulation of the human gut microflora using prebiotics. Gibson GR Br J Nutri 1998; 80:209-212

6. Prolifetation of bifidobacteria by oligosaccharides and their useful effect on human health. Hidaka H, Tashiro Y, Eida T. Bifidobacteria Microflora 1991; 10: 65-79.

7. Dietary nucleotides: cellular immune, intestinal and hepatic system effects. J. Nutr 1994: 124: 144-8s

8. Modulation of the immune system by human milk and infant formula containing nucleotides. Pikering LK, Granoff DM, Erickson JR, Masor ML and cols. American Academy of Pediatrics. 1998; 101: 242-24

9. Nucleotide supplementation and the growth of term small for gestational age infants. Cosgrove M. (1996) Arch Dis Child 74 (f122-f125)

Nutribén® Hidrolizada 1

1. Recomendaciones sobre el uso de fórmulas para el tratamiento y prevención de las reacciones adversas a proteínas de la leche de vaca. Comité de nutrición de la asociación española de pediatría. Anales españoles de pediatría, Vol. 54, nº 4, 2001

2. Safety of a new extensively hydrolysed formula in children with cow’s milk protein allergy: a double blind crossover study Suzanne WJ Terheggen-Lagro, Ilse MSL Khouw, Anne Schaafsma and Erik AK Wauters. BMC Pediatrics 2002, 2:10.

3. The roles of long chain polyunsaturated fatty acids in pregnancy, lactation and infancy: review of the current knowledge and consensus recommendations. B. Koleztko, E. Lien, C. Agostini et al. J. Perinat Med 2008; 36 (1): 5-14.

4. Neurodevelopmental quotient of healthy term infants at 4 months and feeding practice: the role of long chain polyunsaturated fatty acids. C. Agostini, S. Trijan, R. Bellu, E. Riva, M. Giovanni. Pediatr Res 1995; 38: 262-26.

5. Essential fatty acids metabolism and its modifi cation in atopic eczema. David F Horrobin. Am J Clin Nutri 2000; 71 (suppl): 367S-72S.

6. Linolenic acid supplementation for prophylaxis of atopic dermatitis - a randomized controlled trial in infants at high familiar risk. C. JAW van Gool, C. Thijs, C. JM Henquet, A. C. van Houwelingen, P. C. Dagnelie, J. Schrander, P.PCA. Menheere and P.A. van den Brant. The Americal Journal of clinical Nutrition

7. “Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial”. Kalliomäki, M., Salminen, S., Arvilommi, H., Kero, P., Koskinen, P., Isolauri, E., The Lancet, Vol 357, April 7, 2001.

8. Safety and benefits of FOS as food ingredients. Spiegel JE, Rose R, Karabel P, Frankos VH and Schimitt DF. Food Technology. January 1994: 85-89

9. Effects of Fructooligosaccharides on Intestinal Flora and Human Health. Hidaka H. Et al. Bifidobacteria Microflora. 1986, vol.5 (1): 37-50.

10. Alergia alimentaria. Recomendaciones para su prevención. Ferrer Lorente, Nieto García, Dalmau Serra .Acta Pediatr. Esp. 1999; 57: 431-435

11. Dietary products used in infants for treatment and prevention of food allergy.Joint Statement of the ESPACI and ESPGHAN. A,Host, B Koletzko, S Dreborg,A Muraro, U Wahns, P Aggett, J-L, Bresson, O Hernell, H Lafeber, KF Michaelsen, J-L Micheli, J Rigo, L Weaver, H Heymans, S Strobel, Y Vandenplas Arch Dis Child 1999;81:80-84

12. Dietary nucleotides: cellular immune, intestinal and hepatic system effects. J. Nutr 1994: 124: 144-8s

13. Modulation of the immune system by human milk and infant formula containing nucleotides. Pikering LK, Granoff DM, Erickson JR, Masor ML and cols. American Academy of Pediatrics. 1998; 101: 242-24

14. Nucleotide supplementation and the growth of term small for gestational age infants. Cosgrove M. (1996) Arch Dis Child 74 (f122-f125)

Nutribén® Hidrolizada 2

1. Recomendaciones sobre el uso de fórmulas para el tratamiento y prevención de las reacciones adversas a proteínas de la leche de vaca. Comité de nutrición de la asociación española de pediatría. Anales españoles de pediatría, Vol. 54, nº 4, 2001

2. Safety of a new extensively hydrolysed formula in children with cow’s milk protein allergy: a double blind crossover study Suzanne WJ Terheggen-Lagro, Ilse MSL Khouw, Anne Schaafsma and Erik AK Wauters. BMC Pediatrics 2002, 2:10.

3. The roles of long chain polyunsaturated fatty acids in pregnancy, lactation and infancy: review of the current knowledge and consensus recommendations. B. Koleztko, E. Lien, C. Agostini et al. J. Perinat Med 2008; 36 (1): 5-14.

4. Neurodevelopmental quotient of healthy term infants at 4 months and feeding practice: the role of long chain polyunsaturated fatty acids. C. Agostini, S. Trijan, R. Bellu, E. Riva, M. Giovanni. Pediatr Res 1995; 38: 262-26.

5. Essential fatty acids metabolism and its modifi cation in atopic eczema. David F Horrobin. Am J Clin Nutri 2000; 71 (suppl): 367S-72S.

6. Linolenic acid supplementation for prophylaxis of atopic dermatitis - a randomized controlled trial in infants at high familiar risk. C. JAW van Gool, C. Thijs, C. JM Henquet, A. C. van Houwelingen, P. C. Dagnelie, J. Schrander, P.PCA. Menheere and P.A. van den Brant. The Americal Journal of clinical Nutrition

7. “Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial”. Kalliomäki, M., Salminen, S., Arvilommi, H., Kero, P., Koskinen, P., Isolauri, E., The Lancet, Vol 357, April 7, 2001.

8. Safety and benefits of FOS as food ingredients. Spiegel JE, Rose R, Karabel P, Frankos VH and Schimitt DF. Food Technology. January 1994: 85-89

9. Effects of Fructooligosaccharides on Intestinal Flora and Human Health. Hidaka H. Et al. Bifidobacteria Microflora. 1986, vol.5 (1): 37-50.

10. Probiotics: a novel approach in the management of food allergy. Majamaa H, Isolauri E. J. Allergy Clin. Immunol 1997 Feb; 99(2): 179-85

11. Alergia alimentaria. Recomendaciones para su prevención. Ferrer Lorente, Nieto García, Dalmau Serra .Acta Pediatr. Esp. 1999; 57: 431-435

12. Dietary products used in infants for treatment and prevention of food allergy.Joint Statement of the ESPACI and ESPGHAN. A,Host, B Koletzko, S Dreborg,A Muraro, U Wahns, P Aggett, J-L, Bresson, O Hernell, H Lafeber, KF Michaelsen, J-L Micheli, J Rigo, L Weaver, H Heymans, S Strobel, Y Vandenplas Arch Dis Child 1999;81:80-84

13. Dietary nucleotides: cellular immune, intestinal and hepatic system effects. J. Nutr 1994: 124: 144-8s

14. Modulation of the immune system by human milk and infant formula containing nucleotides. Pikering LK, Granoff DM, Erickson JR, Masor ML and cols. American Academy of Pediatrics. 1998; 101: 242-24

15. Nucleotide supplementation and the growth of term small for gestational age infants. Cosgrove M. (1996) Arch Dis Child 74 (f122-f125)

Nutribén® Sin lactosa 1

1. Visual acuity, erythrocyte fatty acid composition and growth in term infants fed formulas with long chain polyunsaturated fatty acid for one year. Auestad N.; Montalvo MB.; Hall RT y Cols: Pediatr Res 1997; 41: 1 – 10

2. The roles of long chain polyunsaturated fatty acids in pregnancy, lactation and infancy: review of the current knowledge and consensus recommendations. B. Koleztko, E. Lien, C. Agostini et al. J. Perinat Med 2008; 36 (1): 5-14.

3. Neurodevelopmental quotient of healthy term infants at 4 months and feeding practice: the role of long chain polyunsaturated fatty acids. C. Agostini, S. Trijan, R. Bellu, E. Riva, M. Giovanni. Pediatr Res 1995; 38: 262-26.

4. Dietary nucleotides: cellular immune, intestinal and hepatic system effects. J. Nutr 1994: 124: 144-8s

5. Modulation of the immune system by human milk and infant formula containing nucleotides. Pikering LK, Granoff DM, Erickson JR, Masor ML and cols. American Academy of Pediatrics. 1998; 101: 242-24

6. Nucleotide supplementation and the growth of term small for gestational age infants. Cosgrove M. (1996) Arch Dis Child 74 (f122-f125)

7. Calcium and zinc absorption from lactose-containing and lactose-free infant formulas Abrams A, Griffin I, Davila P.. Am J. Clin Nutr. 2002; 76:442-6

8. Therapeutic effects of oral zinc in acute and persistent diarrhea in children in developing countries: pooled analysis of randomized controlled trials The Zinc Investigators’ Collaborative Group (Zulfiqar A Bhutta, Sheila M Bird, Robert E Black, Kenneth H Brown, Julie Meeks Gardner, Adi Hidayat, Farida Khatun, Reynaldo Martorell, Nguyen X Ninh, Mary E Penny, Jorge L Rosado, Swapan K Roy, Marie Ruel, Sunil Sazawal, and Anuraj Shankar)

Nutribén® Sin lactosa 2

1. Tratamiento de la diarrea aguda infantil con probióticos: ensayo clínico aleatorizado de cinco preparados terapeuticos. R. Berni Canani, P. Cirillo, G. Terrin, L.Cesarano et cols. BMJ 2007;335:340-345)

2. Dietary nucleotides: cellular immune, intestinal and hepatic system effects. J. Nutr 1994: 124: 144-8s

3. Modulation of the immune system by human milk and infant formula containing nucleotides. Pikering LK, Granoff DM, Erickson JR, Masor ML and cols. American Academy of Pediatrics. 1998; 101: 242-24

4. Nucleotide supplementation and the growth of term small for gestational age infants. Cosgrove M. (1996) Arch Dis Child 74 (f122-f125)

5. Calcium and zinc absorption from lactose-containing and lactose-free infant formulas Abrams A, Griffin I, Davila P.. Am J. Clin Nutr. 2002; 76:442-6

6. Therapeutic effects of oral zinc in acute and persistent diarrhea in children in developing countries: pooled analysis of randomized controlled trials The Zinc Investigators’ Collaborative Group (Zulfiqar A Bhutta, Sheila M Bird, Robert E Black, Kenneth H Brown, Julie Meeks Gardner, Adi Hidayat, Farida Khatun, Reynaldo Martorell, Nguyen X Ninh, Mary E Penny, Jorge L Rosado, Swapan K Roy, Marie Ruel, Sunil Sazawal, and Anuraj Shankar)

Nutribén® Natal HA

1. Investigación sobre la alergenicidad de una fórmula infantil basada en un hidrolizado de suero de leche. Estudio interno según establece el Anexo IV del Real Decreto 867/2008. Datos no publicados.

2. Dietary Whey Protein Hydrolysate Suppresses Development of Atopic Dermatitis-like Skin Lesions Induced by Mite Antigen in NCGNGa Mice. Nobuko Shimizu, Kazuo Dairiki, Saori Ogawa and Tetsuo Kaneko. Allergology International. 2006;55:185-189

Nutribén® Continuación

1. SCIENTIFIC OPINION Scientific Opinion on the substantiation of a health claim related to alpha-linolenic acid and contribution to brain and nerve tissue development pursuant to Article 14 of Regulation (EC) No 1924/20061 EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) 2, 3

2. Scientific Opinion on the substantiation of a health claim related to vitamin C and increasing non-haem iron absorption pursuant to Article 14 of Regulation (EC) No 1924/2006. EFSA Journal 2014;12(1):3514 3 Vitamin D and contribution to the normal function of the immune system: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006 EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA). EFSA Journal 2015; 13 (7): 4182 4 SCIENTIFIC OPINION Scientific Opinion on the substantiation of a health claim related to vitamin D and contribution to normal bone and tooth development pursuant to Article 14 of Regulation (EC) No 1924/20061 EFSA Panel on Dietetic Products, Nutrition and Aller_ies (NDA)2

3. EFSA Journal 2014;12(2):3579 5 La vitamina A contribuye al normal funcionamiento del sistema inmune” Scientific Opinion on the substantiation of a health claim related to vitamin A and contribution to normal development and function of the immune system pursuant to Article 14 of Regulation (EC) No 1924/20061 (EFSA Journal 2013;11(7):3334

Nutribén® Crecimiento

1. REGLAMENTO (CE) N o 983/2009 DE LA COMISIÓN de 21 de octubre de 2009 sobre la autorización o la denegación de autorización de determinadas declaraciones de propiedades saludables en los alimentos relativas a la reducción del riesgo de enfermedad y al desarrollo y la salud de los niños

2. Scientific Opinion on the substantiation of a health claim related to selenium and protection of DNA, proteins and lipids from oxidative damage pursuant to Article 14 of Regulation (EC) No 1924/20061 EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA)2,3 EFSA Journal 2014;12(11):3890

3. REGLAMENTO (CE) N o 957/2010 DE LA COMISIÓN de 21 de octubre de 2009 sobre la autorización o la denegación de autorización de determinadas declaraciones de propiedades saludables en los alimentos relativas a la reducción del riesgo de enfermedad y al desarrollo y la salud de los niños

4. Scientific Opinion on the substantiation of a health claim related to magnesium and contribution to normal development of bone pursuant to Article 14 of Regulation (EC) No 1924/2006 (EFSA Journal 2013;11(7):3331)

5. Scientific Opinion on the substantiation of a health claim related to zinc and normal function of the immune system pursuant to Article 14 of Regulation (EC) No 1924/20061 (EFSA Journal 2014;12(5):3653

6. Scientific Opinion on the substantiation of a health claim related to vitamin A and contribution to normal development and function of the immune system pursuant to Article 14 of Regulation (EC) No 1924/20061 (EFSA Journal 2013;11(7):3334)

7. Scientific Opinion on the substantiation of a health claim related to vitamin D and contribution to normal bone and tooth development pursuant to Article 14 of Regulation (EC) No 1924/20061 (EFSA Journal 2014;12(2):3579) .

8. Vitamin D and contribution to the normal function of the immune system: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006 EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) (EFSA Journal 2015; 13 (7): 4182)

9. Scientific Opinion on the substantiation of a health claim related to thiamine and carbohydrate and energy-yielding metabolism pursuant to Article 14 of Regulation (EC) No 1924/20061 (EFSA Journal 2010;8(7):1690).

10. Scientific Opinion on the substantiation of a health claim related to thiamin and maintenance of normal neurological development and function pursuant to Article 14 of Regulation (EC) No 1924/20061 (EFSA Journal 2011;9(2):1980)

11. Scientific Opinion on the substantiation of a health claim related to riboflavin (vitamin B2) and contribution to normal energy-yielding metabolism pursuant to Article 14 of Regulation (EC) No 1924/20061 (EFSA Journal 2013;11(10):3410

12. Scientific Opinion on the substantiation of a health claim related to vitamin C and increasing non-haem iron absorption pursuant to Article 14 of Regulation (EC) No 1924/20061 (EFSA Journal 2014;12(1):3514

13. Vitamin C and contribution to the normal function of the immune system: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006 (EFSA Journal 2015;13(11):4298)